abstract：AIMS:We used the hospital discharge records of Piedmont region (northern Italy) to evaluate whether a national law banning smoking in public resulted in a short-term reduction in hospital admissions for acute myocardial infarction (AMI). METHODS AND RESULTS:Rates of admission for AMI before the ban (October-December 2...

journal_title：European heart journal

authors： Barone-Adesi F,Vizzini L,Merletti F,Richiardi L

更新日期：2006-10-01 00:00:00

abstract：AIMS:We sought to define the mechanisms and correlates of leptin's vascular actions in humans with coronary artery disease. METHODS AND RESULTS:In 131 patients (age 65.7+/-0.7 years mean+/-SEM), ex vivo vascular reactivity to leptin (10(-13)-10(-7) M) was assessed in saphenous vein (SV) rings. Leptin led to SV relaxat...

journal_title：European heart journal

authors： Momin AU,Melikian N,Shah AM,Grieve DJ,Wheatcroft SB,John L,El Gamel A,Desai JB,Nelson T,Driver C,Sherwood RA,Kearney MT

更新日期：2006-10-01 00:00:00

abstract：AIMS:The object of this study is to analyse the trends in coronary events in Finland during 1993-2002, correcting for the effect of troponins. METHODS AND RESULTS:A population-based myocardial infarction register recorded all coronary events (n=14 782) in four geographical areas of Finland during 1993-2002. Correction...

journal_title：European heart journal

authors： Salomaa V,Ketonen M,Koukkunen H,Immonen-Räihä P,Lehtonen A,Torppa J,Kuulasmaa K,Kesäniemi YA,Pyörälä K,FINAMI Study Group.

更新日期：2006-10-01 00:00:00

abstract：AIMS:To evaluate clinical disease expression, non-invasive diagnosis, and prognosis in families with dominant vs. recessive arrhythmogenic right ventricular cardiomyopathy (ARVC) due to mutations in related desmosomal proteins plakophilin-2 (PKP2) and plakoglobin (JUP), respectively. METHODS AND RESULTS:One hundred an...

journal_title：European heart journal

authors： Antoniades L,Tsatsopoulou A,Anastasakis A,Syrris P,Asimaki A,Panagiotakos D,Zambartas C,Stefanadis C,McKenna WJ,Protonotarios N

更新日期：2006-09-01 00:00:00

abstract：AIMS:The presence of residual thrombus following fibrinolytic therapy for ST-segment elevation myocardial infarction (STEMI) may predispose to greater embolization and microvascular dysfunction. METHODS AND RESULTS:We hypothesized that even in the presence of a patent epicardial artery, residual thrombus would be asso...

journal_title：European heart journal

authors： Kirtane AJ,Vafai JJ,Murphy SA,Aroesty JM,Sabatine MS,Cannon CP,Gibson CM,TIMI Study Group.

更新日期：2006-09-01 00:00:00

abstract：:Randomized clinical trials (RCTs) are the definitive contributors to evidence-based medicine. RCTs assessing serious outcomes in cardiovascular disease have grown, with 'megatrials' becoming more common with the realization that wrong conclusions resulted from random error in inadequately sized trials. Simple design a...

journal_title：European heart journal

authors： Hilbrich L,Sleight P

更新日期：2006-09-01 00:00:00

abstract：AIMS:Serum gamma-glutamyltransferase (GGT) concentration may be involved in atherosclerosis. This study examined if serum GGT predicted coronary heart disease (CHD), especially differentiating non-fatal myocardial infarction (MI) and fatal CHD event, among the general population or participants with type-2 diabetes. M...

journal_title：European heart journal

authors： Lee DH,Silventoinen K,Hu G,Jacobs DR Jr,Jousilahti P,Sundvall J,Tuomilehto J

更新日期：2006-09-01 00:00:00

abstract：AIMS:Treatment of atrial fibrillation remains a major clinical challenge owing to the limited efficacy and safety of anti-arrhythmic drugs, particularly in patients with structural heart disease. METHODS AND RESULTS:To evaluate the efficacy of azimilide, a new class III anti-arrhythmic drug, we studied 658 patients wi...

journal_title：European heart journal

authors： Lombardi F,Borggrefe M,Ruzyllo W,Lüderitz B,A-COMET-II Investigators.

更新日期：2006-09-01 00:00:00

abstract：AIMS:Currently available non-invasive imaging methods frequently fail to detect alterations in left ventricular (LV) function despite histological evidence of injury. Tissue Doppler imaging (TDI) can detect subtle LV dysfunction. The aim of this study was to investigate whether TDI indices can predict LV systolic dysfu...

journal_title：European heart journal

authors： Neilan TG,Jassal DS,Perez-Sanz TM,Raher MJ,Pradhan AD,Buys ES,Ichinose F,Bayne DB,Halpern EF,Weyman AE,Derumeaux G,Bloch KD,Picard MH,Scherrer-Crosbie M

更新日期：2006-08-01 00:00:00

abstract：AIMS:The risk of stroke is greater among women with atrial fibrillation (AF) than men. Warfarin protects against stroke, but treatment-related bleeding occurs more often in women than in men. METHODS AND RESULTS:SPORTIF III (open label, n=3410) and V (double-blind, n=3922) included 2257 women with AF and one or more s...

journal_title：European heart journal

authors： Gomberg-Maitland M,Wenger NK,Feyzi J,Lengyel M,Volgman AS,Petersen P,Frison L,Halperin JL

更新日期：2006-08-01 00:00:00

abstract：AIMS:To assess the safety and effects of combined treatment with vascular endothelial growth factor-A(165) plasmid (VEGF-A(165)) and granulocyte- colony stimulating factor (G-CSF) mobilization of bone marrow stem cells in patients with severe chronic ischaemic heart disease (IHD). METHODS AND RESULTS:Sixteen patients ...

journal_title：European heart journal

authors： Ripa RS,Wang Y,Jørgensen E,Johnsen HE,Hesse B,Kastrup J

更新日期：2006-08-01 00:00:00

abstract：AIMS:No-reflow after a primary percutaneous coronary intervention (PCI) is associated with a high incidence of left ventricular (LV) failure and a poor prognosis. Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide and an important modulator of neutrophil function. Elevated systemic ET-1 levels ...

journal_title：European heart journal

authors： Niccoli G,Lanza GA,Shaw S,Romagnoli E,Gioia D,Burzotta F,Trani C,Mazzari MA,Mongiardo R,De Vita M,Rebuzzi AG,Lüscher TF,Crea F

更新日期：2006-08-01 00:00:00

abstract：AIMS:Left ventricular outflow tract obstruction (LVOTO) is associated with reduced survival in patients with hypertrophic cardiomyopathy (HCM). The influence of LVOTO on survival from SD in relation to other recognized clinical risk markers is unknown. METHODS AND RESULTS:A total of 917 patients with HCM (554 males, 4...

journal_title：European heart journal

authors： Elliott PM,Gimeno JR,Tomé MT,Shah J,Ward D,Thaman R,Mogensen J,McKenna WJ

更新日期：2006-08-01 00:00:00

abstract：AIMS:To explore variations in invasive care of the elderly with acute coronary syndromes across international practice. METHODS AND RESULTS:Using combined populations from the SYMPHONY and 2nd SYMPHONY trials, we describe 30-day cardiac catheterization in elderly (> or = 75 years; n = 1794) vs. younger patients (< 75 ...

journal_title：European heart journal

authors： Alexander KP,Newby LK,Bhapkar MV,White HD,Hochman JS,Pfisterer ME,Moliterno DJ,Peterson ED,Van de Werf F,Armstrong PW,Califf RM,Symphony and 2nd Symphony Investigators.

更新日期：2006-07-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) occurs often in patients after coronary artery bypass grafting (CABG) and can result in increased morbidity and mortality. Previous studies using P-wave signal-averaged electrocardiogram (P-SAECG) have shown that patients with a longer filtered P-wave duration (FPD) have a high risk of AF ...

journal_title：European heart journal

authors： Budeus M,Hennersdorf M,Perings S,Röhlen S,Schnitzler S,Felix O,Reimert K,Feindt P,Gams E,Lehmann N,Wieneke H,Sack S,Erbel R,Perings C

更新日期：2006-07-01 00:00:00

abstract：:Guidelines for the management of cardiovascular disease (CVD) stress the importance of treating global risk, rather than individual risk, factors. Patients at high cardiovascular (CV) risk, for example, benefit from a combination of aspirin, antihypertensive agents, lipid-lowering drugs, and possibly folic acid. As th...

journal_title：European heart journal

authors： Sleight P,Pouleur H,Zannad F

更新日期：2006-07-01 00:00:00

abstract：AIMS:We aimed to assess the increased risk of death and severe vascular events in elderly individuals with subclinical or manifest peripheral arterial disease (PAD), evidenced by low ankle brachial index (ABI < 0.9) in primary care. METHODS AND RESULTS:In this monitored prospective observational study, 6880 representa...

journal_title：European heart journal

authors： Diehm C,Lange S,Darius H,Pittrow D,von Stritzky B,Tepohl G,Haberl RL,Allenberg JR,Dasch B,Trampisch HJ

更新日期：2006-07-01 00:00:00

abstract：AIMS:LV reverse remodelling has been shown to be a favourable response after cardiac resynchronization therapy (CRT) in many clinical trials. This study investigated whether left ventricular (LV) reverse remodelling after CRT has any structural benefit, which include the improvement of LV mass or regional wall thicknes...

journal_title：European heart journal

authors： Zhang Q,Fung JW,Auricchio A,Chan JY,Kum LC,Wu LW,Yu CM

更新日期：2006-06-01 00:00:00

abstract：:Adenosine test (supine administration of a 20 mg intravenous bolus with electrocardiographic and blood pressure monitoring) has been endorsed by the European Society of Cardiology guidelines on syncope management as an 'experimental' test in the diagnosis of unexplained syncope. The test is quick and cheap, but there ...

journal_title：European heart journal

authors： Parry SW,Nath S,Bourke JP,Bexton RS,Kenny RA

更新日期：2006-06-01 00:00:00

abstract：AIMS:The increasing number of adults with congenital heart disease (CHD) has prompted the development of recommendations for the management of these patients and for the organization of their healthcare. The aim of this report is to describe the delivery of care in Europe for adults with congenital cardiac anomalies. ...

journal_title：European heart journal

authors： Moons P,Engelfriet P,Kaemmerer H,Meijboom FJ,Oechslin E,Mulder BJ,Expert Committee of Euro Heart Survey on Adult Congenital Heart Disease.

更新日期：2006-06-01 00:00:00

abstract：AIMS:Release of progenitor cells is observed during inflammatory conditions and contributes to neovascularization. We, therefore, sought to investigate the relationship of circulating progenitor cells and interleukin (IL)-8 in acute myocardial infarction (AMI). METHODS AND RESULTS:From patients with stable angina and ...

journal_title：European heart journal

authors： Schömig K,Busch G,Steppich B,Sepp D,Kaufmann J,Stein A,Schömig A,Ott I

更新日期：2006-05-01 00:00:00

abstract：AIMS:This study was designed to compare the degree of inhibition of platelet aggregation (IPA) of prasugrel with that of clopidogrel in stable aspirin-treated patients with coronary artery disease (CAD). METHODS AND RESULTS:Subjects (n=101) were randomly assigned to the following loading dose (LD) (day 1)/maintenance ...

journal_title：European heart journal

authors： Jernberg T,Payne CD,Winters KJ,Darstein C,Brandt JT,Jakubowski JA,Naganuma H,Siegbahn A,Wallentin L

更新日期：2006-05-01 00:00:00

abstract：AIMS:Chronic kidney disease (CKD) was found to be an independent risk factor for all-cause mortality as well as adverse cardiovascular disease (CVD) events in high-risk populations. Findings from population-based studies are scarce and inconsistent. We investigated the gender-specific association of CKD with all-cause ...

journal_title：European heart journal

authors： Meisinger C,Döring A,Löwel H,KORA Study Group.

更新日期：2006-05-01 00:00:00

abstract：AIMS:We addressed a potential mechanism of myocardial dysfunction following coronary microembolization at the level of myofibrillar proteins. METHODS AND RESULTS:Anaesthetized pigs underwent intracoronary infusion of microspheres. After 6 h, the microembolized areas (MEA) had decreased systolic wall thickening to 38 +...

journal_title：European heart journal

authors： Canton M,Skyschally A,Menabò R,Boengler K,Gres P,Schulz R,Haude M,Erbel R,Di Lisa F,Heusch G

更新日期：2006-04-01 00:00:00

abstract：AIMS:Periconceptional folate supplementation prevents neural tube defects and possibly congenital heart defects (CHD) as well. The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism. We studied the association between MTHFR 677C > ...

journal_title：European heart journal

authors： van Beynum IM,Kapusta L,den Heijer M,Vermeulen SH,Kouwenberg M,Daniëls O,Blom HJ

更新日期：2006-04-01 00:00:00

abstract：AIMS:Although embolic protection devices reduce complications during saphenous vein graft (SVG) stenting, adverse events still occur in approximately 10% of patients. IIb/IIIa antagonists have not been proven effective during SVG intervention. We hypothesized that adjunctive use of these agents might enhance the effica...

journal_title：European heart journal

authors： Jonas M,Stone GW,Mehran R,Hermiller J,Feldman R,Herrmann HC,Cox DA,Kuntz RE,Popma JJ,Rogers C,FilterWire EX Randomized Evalulation (FIRE) Investigators.

更新日期：2006-04-01 00:00:00

abstract：AIMS:Sirolimus- and paclitaxel-eluting stents effectively reduce restenosis in small coronary vessels. The relative efficacy of these drug-eluting stents in this high-risk subset is not known. METHODS AND RESULTS:A total of 360 patients undergoing percutaneous coronary intervention for de novo lesions in native corona...

journal_title：European heart journal

authors： Mehilli J,Dibra A,Kastrati A,Pache J,Dirschinger J,Schömig A,Intracoronary Drug-Eluting Stenting to Abrogate Restenosis in Small Arteries (ISAR-SMART 3) Study Investigators.

更新日期：2006-02-01 00:00:00

abstract：AIMS:Assessment of N-terminal brain natriuretic peptide (NT-BNP) as a screening tool for heart failure in patients with a permanent pacemaker. METHODS AND RESULTS:Consecutive patients undergoing a routine permanent pacemaker assessment were enrolled. Patients underwent medical history and examination, echocardiography...

journal_title：European heart journal

authors： Thackray SD,Witte K,Ghosh J,Nikitin N,Anderson A,Rigby A,Goode K,Clark AL,Cleland JG

更新日期：2006-02-01 00:00:00

abstract：AIMS:Atrial fibrillation (AF) is a common complication in patients with acute myocardial infarction and is associated with an increase in the risk of death. The excess mortality associated with AF complicating acute myocardial infarction has not been studied in detail. Observations indicate that AF facilitates inductio...

journal_title：European heart journal

authors： Pedersen OD,Abildstrøm SZ,Ottesen MM,Rask-Madsen C,Bagger H,Køber L,Torp-Pedersen C,TRACE Study Investigators.

更新日期：2006-02-01 00:00:00

abstract：AIMS:To determine what proportion of patients with heart failure are eligible for cardiac resynchronization therapy (CRT). METHODS AND RESULTS:Eligibility criteria from the trials establishing the efficacy of CRT were applied to two prospective cohorts: the first enrolled patients with newly diagnosed heart failure di...

journal_title：European heart journal

authors： McAlister FA,Tu JV,Newman A,Lee DS,Kimber S,Cujec B,Armstrong PW

更新日期：2006-02-01 00:00:00

abstract：:There is mounting evidence to support the influence of inflammation in the pathogenesis of atrial fibrillation (AF). Indeed, AF is associated with increased levels of known inflammatory markers, even after adjustment for confounding factors. The renin-angiotensin-aldosterone system (RAAS) appears to play a key role in...

journal_title：European heart journal

authors： Boos CJ,Anderson RA,Lip GY

更新日期：2006-01-01 00:00:00

abstract：AIMS:The anti-anginal efficacy and safety of ranolazine in diabetic and non-diabetic patients included in the Combination Assessment of Ranolazine In Stable Angina (CARISA) trial (JAMA 2004;291:309) were studied. Glycaemic control was also assessed in CARISA and its long-term open-label extension study. METHODS AND RE...

journal_title：European heart journal

authors： Timmis AD,Chaitman BR,Crager M

更新日期：2006-01-01 00:00:00

abstract：AIMS:Metalloproteinases are proteolytic enzymes, which decompose the extracellular matrix, influence cardiac remodelling, and are inhibited by tissue inhibitor of metalloproteinases (TIMPs). Little is known about the prognostic impact of the TIMP-1/matrix metalloproteinase complex in patients with future cardiovascular...

journal_title：European heart journal

authors： Lubos E,Schnabel R,Rupprecht HJ,Bickel C,Messow CM,Prigge S,Cambien F,Tiret L,Münzel T,Blankenberg S

更新日期：2006-01-01 00:00:00

abstract：:Both epidemiological studies and intervention trials support an important role of diet in reducing the risk of a variety of chronic diseases, including cardiovascular disease, and overall mortality. We discuss available evidence indicating that the generation of a pro-inflammatory milieu might be one mechanism through...

journal_title：European heart journal

authors： Esposito K,Giugliano D

更新日期：2006-01-01 00:00:00

abstract：AIMS:The guidelines of the European Society of Cardiology (ESC) define the current standard for the management of syncope, but are still incompletely applied in the clinical setting. METHODS AND RESULTS:Prospective systematic evaluation, on strict adherence to the guidelines, of consecutive patients referred for synco...

journal_title：European heart journal

authors： Brignole M,Menozzi C,Bartoletti A,Giada F,Lagi A,Ungar A,Ponassi I,Mussi C,Maggi R,Re G,Furlan R,Rovelli G,Ponzi P,Scivales A

更新日期：2006-01-01 00:00:00

abstract：AIMS:Ivabradine, a new I(f) inhibitor which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. Ivabradine has shown anti-ischaemic and anti-anginal activity in a placebo-controlled trial. The objective of this study was to compare the anti-anginal and anti-ischaemic...

journal_title：European heart journal

authors： Tardif JC,Ford I,Tendera M,Bourassa MG,Fox K,INITIATIVE Investigators.

更新日期：2005-12-01 00:00:00

abstract：AIMS:To study the implications of European guidelines on the use of antihypertensives and/or lipid-lowering drugs (LLDs) for primary prevention in a Norwegian population. METHODS AND RESULTS:The Tromsø study is a population-based study in the municipality Tromsø, Norway (from 1974 to till now). This analysis includes ...

journal_title：European heart journal

authors： Hartz I,Njølstad I,Eggen AE

更新日期：2005-12-01 00:00:00

abstract：AIMS:Anaemia is often observed in patients with chronic heart failure (CHF), and it may be associated with a worse prognosis. Aim of this study was to identify the individual mechanisms of anaemia in CHF patients. METHODS AND RESULTS:One hundred and forty-eight consecutive patients with haemoglobin concentration <13 g...

journal_title：European heart journal

authors： Opasich C,Cazzola M,Scelsi L,De Feo S,Bosimini E,Lagioia R,Febo O,Ferrari R,Fucili A,Moratti R,Tramarin R,Tavazzi L

更新日期：2005-11-01 00:00:00

abstract：AIMS:To determine the potential adjunct of high-sensitivity (hs) C-reactive protein for risk stratification in patients with stable congestive heart failure (CHF). METHODS AND RESULTS:We studied 546 consecutive patients clinically stable with an ejection fraction <45% who were referred to our centre for evaluation of ...

journal_title：European heart journal

authors： Lamblin N,Mouquet F,Hennache B,Dagorn J,Susen S,Bauters C,de Groote P

更新日期：2005-11-01 00:00:00

abstract：AIMS:To investigate the subacute effects of a sustained intravenous infusion of urocortin-I (Ucn-I) in experimental heart failure (HF). METHODS AND RESULTS:In eight sheep with pacing-induced HF, a 4-day infusion of Ucn-I (0.3 microg/kg/h) induced prompt (30 min) and sustained (4-day) increases in cardiac output (CO, D...

journal_title：European heart journal

authors： Rademaker MT,Charles CJ,Espiner EA,Frampton CM,Lainchbury JG,Richards AM

更新日期：2005-10-01 00:00:00